性做久久久久久坡多野结衣-性做久久久久久久久浪潮-性欲影院-性影院-国产精品线路一线路二-国产精品兄妹在线观看麻豆

產品展廳收藏該商鋪

您好 登錄 注冊

當前位置:
美國布魯克海文儀器公司>技術文章>Design, synthesis and evaluation of multi-functional tLyP-1-hyaluronic acid-paclitaxel conjugate end

技術文章

Design, synthesis and evaluation of multi-functional tLyP-1-hyaluronic acid-paclitaxel conjugate end

閱讀:605          發布時間:2017-10-18
 作者 Weiqin Wanga. Mengying Lia. Zhenhai Zhangb. Changchang Cuia. Jianping Zhoua. Lifang Yina. Huixia Lva.

a

Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 210009, China

b

Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, 210028, China

 

摘要:A novel tLyP-1-HA-PTX conjugate is designed for combining the solubilization capacity of Paclitaxel (PTX) and tumor tissue targeting – penetration effect of hyaluronic acid (HA) as well as cell penetration peptide (tLyP-1). In addition, through modifying by tLyP-1, the anticancer scope of tLyP-1-HA-PTX conjugate was expanded from tumor cells expressing CD44 receptors to those of expressing NRP1 receptors. In vitro antitumor ability of tLyP-1-HA-PTX conjugate and cellular uptake tests were conducted to testify the tumor-targeting behavior of the conjugates. The results showed that both HA-PTX and tLyP-1-HA-PTX conjugates gained better solubility, better stability and specific tumor sites ability and showed high safety in vitro cytotoxicity tests. The tLyP-1-HA-PTX conjugate was especially endowed with efficient cell-penetrating and tumor NRP1 receptor targeting ability and compensate for the decreasing of uptake caused by suppression of CD44 receptor, which is more significant when NRP1 receptor is highly expressed.

收藏該商鋪

登錄 后再收藏

提示

您的留言已提交成功!我們將在第一時間回復您~

對比框

產品對比 產品對比 聯系電話 二維碼 意見反饋 在線交流

掃一掃訪問手機商鋪
010-62081908
在線留言
主站蜘蛛池模板: 汕头市| 宜章县| 瑞金市| 兰西县| 思南县| 淳安县| 雅安市| 南华县| 东兰县| 高青县| 徐汇区| 南陵县| 屏边| 钟山县| 孟村| 宁安市| 海宁市| 嘉定区| 资溪县| 宾阳县| 彰化市| 长治市| 塘沽区| 沧源| 南阳市| 廉江市| 泰顺县| 萨迦县| 灵宝市| 高台县| 琼结县| 明水县| 涡阳县| 滁州市| 卢氏县| 鞍山市| 白沙| 三门峡市| 菏泽市| 正定县| 邓州市|