性做久久久久久坡多野结衣-性做久久久久久久久浪潮-性欲影院-性影院-国产精品线路一线路二-国产精品兄妹在线观看麻豆

產品展廳收藏該商鋪

您好 登錄 注冊

當前位置:
美國布魯克海文儀器公司>技術文章>Topotecan-loaded lipid nanoparticles as a viable tool for the topical treatment of skin cancers

技術文章

Topotecan-loaded lipid nanoparticles as a viable tool for the topical treatment of skin cancers

閱讀:326          發布時間:2017-8-17
 作者 João Hélio Venâncio, Lígia Marquez Andrade, Najla Locali Santos Esteves, Lara Barroso Brito, Marize Campos Valadares, Gisele Augusto Rodrigues Oliveira, Eliana Martins Lima, Ricardo Neves Marreto, Tais Gratieri, Stephânia Fleury Taveira

 

 

摘要:

Objectives

 

This work aimed to evaluate semisolid formulations containing topotecan (TPT) loaded nanostructured lipid carriers (NLC) for topical treatment of skin cancers, as TPT is effective against a variety of tumours. A formulation which increases TPT skin permeation would be extremely desirable.

Methods

 

TPT-NLC were prepared and incorporated in hydrogels with hydroxyethyl cellulose and chitosan (TPT-NLC-HEC and TPT-NLC-Ch, respectively). Control formulations were obtained by dispersing TPT in HEC and Ch hydrogels (TPT-HEC and TPT-Ch).

Key findings

 

TPT-NLC-HEC and TPT-NLC-Ch showed to maintain the drug and nanoparticle dispersions stable for up to 30 days. When nanoparticles were incorporated into gels, TPT release was significantly decreased (P < 0.05). Still, TPT-NLC-HEC increased 2.37 times permeation compared with TPT-HEC (11.9 and 5.0 μg/cm2, respectively). Cell culture experiments with B16F10 melanoma demonstrated that nanoencapsulation significantly increased TPT cytotoxicity (P < 0.05). TPT-NLC was more toxic than free TPT, with IC50 value of 5.74 μg/ml, whereas free TPT had an IC50 > 20 μg/ml. As skin permeated values of TPT from developed formulation (TPT-NLC) were superior to melanoma IC50, it can be extrapolated that chemotherapeutic permeated amounts may be sufficient for a therapeutic effect.

Conclusions

 

TPT-NLC-HEC may be a valuable tool for the topical treatment of skin cancers.

收藏該商鋪

登錄 后再收藏

提示

您的留言已提交成功!我們將在第一時間回復您~

對比框

產品對比 產品對比 聯系電話 二維碼 意見反饋 在線交流

掃一掃訪問手機商鋪
010-62081908
在線留言
主站蜘蛛池模板: 汕尾市| 红原县| 湛江市| 奇台县| 丰顺县| 美姑县| 巴彦淖尔市| 乐业县| 大洼县| 洪湖市| 清新县| 会泽县| 衡阳市| 通州市| 洱源县| 德令哈市| 双柏县| 宜章县| 泽库县| 阿巴嘎旗| 灵山县| 芒康县| 翁源县| 嵊州市| 江阴市| 茌平县| 大名县| 达州市| 宁津县| 囊谦县| 千阳县| 宝应县| 延津县| 宣汉县| 尉氏县| 乐清市| 太保市| 安塞县| 墨竹工卡县| 平昌县| 陆河县|