性做久久久久久坡多野结衣-性做久久久久久久久浪潮-性欲影院-性影院-国产精品线路一线路二-国产精品兄妹在线观看麻豆

CXADR （coxsackie virus and adenovirus receptor）, also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family within the immunoglobulin （Ig） superfamily. It plays a crucial role in normal cardiac development in mice. CXADR is proposed to function as a homophilic cell adhesion molecule and is a component of the epithelial apical junction complex, which is essential for maintaining tight junction integrity. It is also likely involved in the transepithelial migration of polymorphonuclear leukocytes （PMNs）.
The mature mouse CXADR structure comprises a 218 amino acid （aa） extracellular domain （ECD）, which includes a V-type （D1） and a C2-type （D2） Ig-like domain, a 21 aa transmembrane segment, and a 17 aa intracellular domain. Notably, D1 is believed to be responsible for homodimer formation within tight junctions. The ECD of mouse CXADR shares 97% sequence identity with the corresponding regions of human CXADR and 9% sequence identity with those of rat CXADR.