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Wnt surrogate protein is an engineered Fc fusion protein, which activates similar Wnt signaling pathways as most commercially available recombinant Wnt3a proteins or Wnt-conditioned media, while requiring a fraction of the amount of protein or hassle. It is necessary for cell proliferation and differentiation and the self-renewal of stem cells and is widely used for supporting organoid culture, including intestinal, stomach, liver, lung organoids. Modulation of WNT signaling pathways has potential for treatment of degenerative diseases and tissue injuries. This engineered Wnt surrogate protein can be selective for individual FZD or a subfamily of FZDs in combination with LRP5 or LRP6, depending on the binder specificities, and may be used in any of a variety of therapeutic methods for the treatment of diseases.

Recombinant Human Wnt3a Surrogate Protein activates Wnt signaling pathways and is necessary for cell proliferation and differentiation and the self-renewal of stem cells. It is widely used for supporting organoid culture, including intestinal, stomach, liver, lung organoids.