性做久久久久久坡多野结衣-性做久久久久久久久浪潮-性欲影院-性影院-国产精品线路一线路二-国产精品兄妹在线观看麻豆

Osteopontin （OPN） is a protein that in humans is encoded by the SPP1 gene （secreted phosphoprotein 1）. The murine ortholog is Spp1. Osteopontin is a SIBLING （glycoprotein） that was first identified in 1986 in osteoblasts. Osteopontin is an extracellular structural protein and therefore an organic component of bone. The fact that OPN interacts with multiple cell surface receptors that are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation, ischemia, and immune responses. Manipulation of plasma （or local） OPN levels may be useful in the treatment of autoimmune diseases, cancer metastasis, bone （and tooth） mineralization diseases, osteoporosis, and some forms of stress.