目錄:杭州斯達特生物科技有限公司>>抗體/抗原>>病理/IHC抗體>> S0B2315MDR1/ABCB1 Recombinant Rabbit mAb (SDT-872-21)
MDR1 is a member of the superfamily of ATP-binding cassette （ABC） transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
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