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CD63 is a tetraspanin protein involved in various cellular processes such as cell adhesion, migration, and signal transduction. It is predominantly found on the membranes of late endosomes, multivesicular bodies, and exosomes. As a marker protein of exosomes, CD63 plays a crucial role in cell-to-cell communication, including facilitating the interaction between tumor cells and surrounding cells. Additionally, CD63 is associated with intracellular secretory events in cells like eosinophils, where it is involved in degranulation processes. In some cancers, such as hepatocellular carcinoma, CD63-overexpressing tumor-associated macrophages can drive tumor progression by promoting cancer cell proliferation, migration, and invasion.