目錄:MedChemExpress LLC>>信號通路>> Paricalcitol | 帕立骨化醇 | MedChemExpress (MCE)
| CAS | 131918-61-1 | 純度 | 99.96% |
|---|---|---|---|
| 分子量 | 416.64 | 分子式 | C??H??O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 1 mg |
| 貨號 | HY-50919 | 應用領域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務。
CAS No. : 131918-61-1
MCE 國際站：Paricalcitol
產(chǎn)品活性：Paricalcitol 是 vitamin D 類似物，是有效的 vitamin D receptor 的激活劑，用于研究繼發(fā)性甲狀旁腺功能亢進 (分泌過多的甲狀旁腺激素)，該疾病與慢性腎功能衰竭有關。
研究領域：Vitamin D Related/Nuclear Receptor
作用靶點：VD/VDR
In Vitro: Paricalcitol (3×10-8 M; HP + PC) produces a significant reduction in calcification relative to the observed in cells in HP medium. Paricalcitol causes a reduction in the levels of nuclear β-catenin to a level similar to that observed in control cells.
In Vivo: Paricalcitol (300 ng/kg/day) significantly decreases Tau, and prevents LV dysfunction in mice. Paricalcitol reduces mRNA expression of ANP, fibronectin and collagen III in the TAC-pari mice.
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