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BPS Bioscience Inc.
中級會員 | 第3年

13829799985

當前位置:BPS Bioscience Inc.>>試劑>>克隆與表達>> Spike (B.1.617.2.1; Delta Plus Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)

Spike (B.1.617.2.1; Delta Plus Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)

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更新時間:2024-11-23 16:16:36瀏覽次數:175次

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保存條件:-80°C(dryice)保質期:3-18month英文名:Spike(B
  • 保存條件:

    -80°C (dry ice)

  • 保質期:

    3-18 month

  • 英文名:

    Spike (B.1.617.2.1; Delta Plus Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)

  • 數量:

    1

  • 供應商:

    BPS Bioscience Inc.

  • CAS號:

    /

  • 規格:

    100 µl

The pandemic coronavirus disease 2019 () is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection. A variant called B.1.617.2.1 (also known as the Delta Plus Variant) was identified in India in the spring of 2021. This variant has a number of mutations that increase morbidity and mortality and allow the virus to spread more easily and quickly than other variants.The Spike (B.1.617.2.1 Variant) (SARS-CoV-2) Pseudotyped Lentiviruses were produced with SARS-CoV-2 B.1.617.2.1 Variant Spike (Genbank Accession #QHD43416.1 with B.1.617.2.1 mutations; see below for details) as the envelope glycoproteins instead of the commonly used VSV-G. Compared to the Delta variant (B.1.617.2), variant Delta Plus has additional mutation K417N. These pseudovirions contain the enhanced green fluorescent protein (eGFP) reporter gene driven by a CMV promoter, therefore, the spike-mediated cell entry can be determined via eGFP fluorescence. The Spike (B.1.617.2.1 Variant) (SARS-CoV-2) pseudotyped lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 B.1.617.2.1 variant in a Biosafety Level 2 facility.
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