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Source

Rabbit

Applications

WB

Reactivity

Human, Mouse,Rat

Dilution

WB 1：500-2000

Storage

-20°C/1 year

Specificity

This antibody detects endogenous levels of BYST at Human/Mouse/Rat

Source/Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen

Synthesized peptide derived from human BYST

Uniprot No

Q13895

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008],

Other

BYSL, BYST

Mol.Wt (Da)

48070

Concentration

1 mg/ml