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Source

Rabbit

Applications

WB

Reactivity

Human,Mouse

Dilution

WB 1:1000-2000

Storage

-20°C/1 year

Specificity

This antibody detects endogenous levels of Human Mouse Bim (phospho-Ser69)

Source/Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen

Synthesized phosho peptide around human Bim (Ser69)

Uniprot No

O43521

Alternative names

Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

BCL2 like 11(BCL2L11) Homo sapiens The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013],

Other

BCL2L11 BIM, Bim (Ser69)

Concentration

1 mg/ml