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Source

Rabbit

Applications

IHC,ELISA

Reactivity

Human,Mouse

Dilution

IHC: 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

BinCARD Polyclonal Antibody detects endogenous levels of BinCARD protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human C9orf89. AA range:21-70

Uniprot No

Q96LW7

Alternative names

C9orf89; Bcl10-interacting CARD protein; BinCARD

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 CARD domain.,subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol.,subunit:Associates with BCL10 by CARD-CARD interaction.,tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.,

Other

C9orf89, Bcl10-interacting CARD protein

Mol.Wt (Da)

25589

Concentration

1 mg/ml