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Source

Rabbit

Applications

WB,IHC,IF,ELISA

Reactivity

Human,Mouse,Rat

Dilution

WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. IF: 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

Phospho-Bcl-x (T47) Polyclonal Antibody detects endogenous levels of Bcl-x protein only when phosphorylated at T47.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human BCL-XL around the phosphorylation site of Thr47. AA range:13-62

Uniprot No

Q07817

Alternative names

BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

BCL2 like 1(BCL2L1) Homo sapiens The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015],

Other

BCL2L1, Bcl-2-like protein 1

Mol.Wt (Da)

26049

Concentration

1 mg/ml