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Source

Rabbit

Applications

WB,ELISA

Reactivity

Human,Mouse,Rat

Dilution

WB: 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

BRE Polyclonal Antibody detects endogenous levels of BRE protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human BRE. AA range:325-374

Uniprot No

Q9NXR7

Alternative names

BRE; BRCC45; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

brain and reproductive organ-expressed (TNFRSF1A modulator)(BRE) Homo sapiens This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strａnd DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016],

Other

BRE, BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein

Mol.Wt (Da)

46974

Concentration

1 mg/ml