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Source

Rabbit

Applications

WB,IHC,ELISA

Reactivity

Human

Dilution

IHC: 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

Phospho-BRCA1 (S1524) Polyclonal Antibody detects endogenous levels of BRCA1 protein only when phosphorylated at S1524.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human BRCA1 around the phosphorylation site of Ser1524. AA range:1491-1540

Uniprot No

P38398

Alternative names

BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

BRCA1, DNA repair associated(BRCA1) Homo sapiens This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian

Other

BRCA1, Breast cancer type 1 susceptibility protein

Mol.Wt (Da)

207721

Concentration

1 mg/ml