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Source

Rabbit

Applications

WB

Reactivity

Human

Dilution

WB 1:500-2000

Storage

-20°C/1 year

Specificity

This antibody detects endogenous levels of human Bmi-1

Source/Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen

Recombinant Protein derived from human Bmi-1

Uniprot No

P35226

Alternative names

Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

BMI1 proto-oncogene, polycomb ring finger(BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],

Other

BMI1 PCGF4 RNF51, Bmi-1

Concentration

1 mg/ml