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Source

Mouse

Applications

WB,IF,IHC

Reactivity

Human,Mouse,Rat

Dilution

WB: 1:1000-2000 IHC: 1:200-500 IF 1:200

Storage

-20°C/1 year

Specificity

The antibody detects endogenous Catenin-β protein.

Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

Immunogen

Recombinant Protein of Catenin-β

Uniprot No

P35222

Alternative names

CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin

Form

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Clonality

Monoclonal

Isotype

IgG

Background

catenin beta 1(CTNNB1) Homo sapiens The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016],

Other

CTNNB1, Catenin beta-1

Concentration

1 mg/ml