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Source

Rabbit

Applications

WB,IF,ELISA

Reactivity

Human

Dilution

WB: 1:500 - 1:2000. IF: 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

CD137L Polyclonal Antibody detects endogenous levels of CD137L protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human TNFSF9. AA range:31-80

Uniprot No

P41273

Alternative names

TNFSF9; Tumor necrosis factor ligａnd superfamily member 9; 4-1BB ligand; 4-1BBL

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

tumor necrosis factor superfamily member 9(TNFSF9) Homo sapiens The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligａnd family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligａnd for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligａnd encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided b

Other

TNFSF9, Tumor necrosis factor ligａnd superfamily member 9

Mol.Wt (Da)

26625

Concentration

1 mg/ml