Smartox Biotechnology是*一家專門生產動物毒液多肽毒素，用于細胞離子通道功能研究的生物醫藥公司。多肽毒素在生物制藥領域具有重要的使用價值。

Charybdotoxin /ChTx

 

K_Ca²⁺ channel blocker(KCa2+ 通道阻斷劑)

 

Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca²⁺ activated K⁺ channels K_Ca1.1 in nanomolar concentrations (IC₅₀~ 3 nM). This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocksK_Ca3.1 (IC₅₀ 5 nM), K_v1.2 (IC₅₀ 14 nM), K_v1.3 (IC₅₀ 2.6 nM) and K_v1.6 (IC₅₀ 2 nM) channels.

 

ChTx技術資料

氨基酸序列：

H-Pyr-Phe-Thr-Asn-Val-Ser-Cys⁷-Thr-Thr-Ser-Lys-Glu-Cys¹³-Trp-Ser-Val-Cys¹⁷-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys²⁸-Met-Asn-Lys-Lys-Cys³³-Arg-Cys³⁵-Tyr-Ser-OH 

二硫鍵：Disulfide bonds between Cys⁷-Cys²⁸, Cys¹³-Cys³³, and Cys¹⁷-Cys³⁵

長度（aa）： 37 

分子式：C₁₇₆H₂₇₇N₅₇O₅₅S₇ 

分子量： 4295.90 Da 

外觀：White lyophilized solid 

可溶性： water and saline buffer 

CAS 號：95751-30-7 

來源：Synthetic 

純度：> 97%

 

產品信息

11CHA001-00050	Charybdotoxin	0.05mg
11CHA001-00100	Charybdotoxin	0.1mg
11CHA001-00500	Charybdotoxin	0.5mg
11CHA001-01000	Charybdotoxin	1mg