| I. Background | |
FGFR2B 是成纖維細胞生長因子受體 2（FGFR2）的剪接變體之一，屬于受體激酶（RTK）家族，由胞外配體結合域（含三個免疫球蛋白樣結構域）、跨膜區及胞內激酶域組成。其特異性由外顯子 IIIb 的選擇性剪接決定，主要在上皮細胞表達，與間質細胞來源的 FGFR2C（IIIc 剪接變體）形成旁分泌信號軸，調控上皮-間質相互作用。 | |
II. Introduction | |
Host Cell: | MC-38 |
Expressed gene: | hFGFR2b |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | DMEM+10%FBS+2μg/ml Puromycin |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
III. Description of Host Cell Line | |
Organism: | Mus musculus, mouse |
Tissue: | Colon |
Morphology: | Epitheloid cell |
Growth Properties: | Adherent |
IV. Representative Data | |
Figure 1. Recombinant hFGFR2b/MC-38 stably expressing hFGFR2b. | |
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