Claudin18.2/AGS Claudin18.2/AGS Claudin18.2/AGS
| I. Background | |
Claudin18是位于細胞膜表面緊密連接的主要成分，它在維持細胞極性和屏障功能以及促進耐酸能力方面起著重要作用。CLDN18的第一個外顯子可以選擇性剪接，形成兩個具有高度同源氨基酸序列的不同剪接突變體(CLDN18.1和CLDN18.2)。跨膜蛋白CLDN18由兩個細胞外環(huán)、四個跨膜結(jié)構(gòu)域和一個細胞質(zhì)結(jié)構(gòu)域組成。 | |
| II. Introduction | |
| Host Cell: | AGS |
| Expressed gene: | Claudin18.2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| III. Description of Host Cell Line | |
| Species: | Homo sapiens, human |
| Tissue: | Stomach |
| Disease: | Gastric adenocarcinoma |
| Morphology: | Epitheloid |
| Growth Properties: | Adherent |
| IV. Representative Data | |
1. Claudin18.2/AGS | |
Figure 1. Recombinant Claudin18.2/AGS stably expressing Claudin18.2. | |
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