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CBP10288 | |
| Format | Genomic DNA |
| Description | HRAS G12D is hotspot mutation that lies within the GTP binding domain of the Hras protein (UniProt.org). G12D results in decreased Hras GTPase activity, loss of sensitivity to GTPase-activating proteins, thus leads to transformation of cells in culture (PMID: 24224811, PMID: 6092966). |
| Technical Data | |
| DNA Change | c.35G>A |
| AA Change | p.G12D |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000397596 |
| Cosmic ID | COSM484 |
| Chr position(GRCh37) | chr11:534288 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
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| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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