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當(dāng)前位置：南京科佰生物科技有限公司>>基因檢測標(biāo)準(zhǔn)品>>Mutation>> CBP10240BRAF p.L597R Reference Standard 標(biāo)準(zhǔn)品

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產(chǎn)品型號CBP10240

品牌cobioer/科佰生物

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產(chǎn)品簡介

供貨周期	現(xiàn)貨	規(guī)格	1ug
貨號	CBP10240	應(yīng)用領(lǐng)域	生物產(chǎn)業(yè)

BRAF p.L597R Reference Standard

CBP10240
Format	Genomic DNA
Description	BRAF L597R lies within the protein kinase domain of the Braf protein (UniProt.org). L597R results in activation of Braf as indicated by increased phosphorylation of Mek and Erk in cell culture (PMID: 22798288, PMID: 26343582), is associated with Erk activation in a patient tumor sample (PMID: 23715574), and in one of two cell lines, increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785).

Technical Data
DNA Change	c.1790T>G
AA Change	p.L597R
Mutation type	Substitution - Missense
Zygosity	Heterozygous
Allelic Frequency	50.00%
Transcript	ENST00000288602
Cosmic ID	COSM471
Chr position(GRCh37)	chr7:140453145
Buffer	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing
Storage	4℃
Expiry	36 months from the date of manufacture