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產(chǎn)品型號(hào)CBP10236

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供貨周期	現(xiàn)貨	規(guī)格	1ug
貨號(hào)	CBP10236	應(yīng)用領(lǐng)域	生物產(chǎn)業(yè)

BRAF p.G469R Reference Standard

CBP10236
Format	Genomic DNA
Description	BRAF G469R is a hotspot mutation within the protein kinase domain of the Braf protein (UniProt.org). G469R demonstrates intermediate BRAF kinase activity (PMID: 28783719) and results in constitutive ERK activation in cell culture (PMID: 24920063), and in one of two cell lines leads to increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785), and is therefore predicted to confer a gain of function to the Braf protein.

Technical Data
DNA Change	c.1405G>A
AA Change	p.G469R
Mutation type	Substitution - Missense
Zygosity	Heterozygous
Transcript	ENST00000288602
Cosmic ID	COSM457
Chr position(GRCh37)	chr7:140481403
Buffer	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing	Download for COA
Storage	4℃
Expiry	36 months from the date of manufacture