| Panel-Ref® gDNA Cocktail I Reference Standard | ||||||||
| Cat No. | CBP90008 | |||||||
| Format | Genomic DNA | |||||||
| Description | 包含常見基因的重要位點，涉及EGFR/BRAF/PIK3CA/ERBB2/KRAS等基因 | |||||||
| Gene | AA Change | CDS Change | Exon | Cosmic ID | Expected AF | DdPCR AF | NGS AF | Chr position (GRCh37) |
| EGFR | p.E746_A750delELREA | c.2235_2249del15 GGAATTAAGAGAAGC>- | 19 | COSM6223 | 7.50% | 7.50% | 7.12% | chr7:55242465_55242479 |
| EGFR | p.G719A | c.2156G>C | 18 | COSM6239 | 5.00% | 5.50% | 5.59% | chr7:55241708 |
| EGFR | p.S768I | c.2303G>T | 20 | COSM6241 | 5.00% | 4.80% | 5.89% | chr7:55249005 |
| EGFR | p.T790M | c.2369C>T | 20 | COSM6240 | 10.00% | 11.00% | 9.14% | chr7:55249071 |
| EGFR | p.L858R | c.2573T>G | 21 | COSM6224 | 10.00% | 10.20% | 10.76% | chr7:55259515 |
| ERBB2 | p.A775_G776insYVMA | c.2324_2325ins12 ATACGTGATGGC | 20 | COSM20959 | 5.00% | N/A | 4.55% | chr17:37880995_37880996 |
| KRAS | p.G13D | c.38G>A | 2 | COSM532 | 9.00% | 9.70% | 9.19% | chr12:25398281 |
| BRAF | p.V600E | c.1799T>A | 15 | COSM476 | 58.00% | 57.40% | 52.89% | chr7:140453136 |
| PIK3CA | p.H1047R | c.3140A>G | 20 | COSM775 | 50.00% | 50.00% | 48.99% | chr3:178952085 |
| BRCA1 | p.D435Y | c.1303G>T | 10 | COSM3190122 | 41.21% | N/A | 39.04% | chr17:41246245 |
| BRCA2 | p.Q1782fs | c.5345A>- | 11 | COSM18607 | 35.00% | N/A | 33.45% | N/A |
| BRCA2 | p.I2675fs*6 | c.8015_8016insA | 18 | COSM2071519 | 10.00% | N/A | 10.65% | chr13:32937360 |
| CTNNB1 | p.S45del | c.131_133delCTT | 3 | COSM6128 | 9.00% | N/A | 9.69% | chr3:41266136_41266138 |
| APC | p.K1454E | c.4360A>G | 17 | COSM27993 | 41.21% | N/A | 41.47% | chr5:112175651 |
| FGFR2 | p.P582L | c.1745C>T | 13 | COSM1675615 | 7.69% | N/A | 8.17% | chr10:123256164 |
| IDH2 | p.G190D | c.569G>A | 5 | COSM2139737 | 41.21% | N/A | 39.45% | chr15:90631700 |
| MSI Inspection Data | ||||||||
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| Product Information | ||||||||
| Intended Use | Research Use Only | |||||||
| Unit Size | 1ug/vial * 1 vial | |||||||
| Concentration | Download for COA | |||||||
| Purity | Download for COA | |||||||
| DNA electrophoresis | Download for COA | |||||||
| Storage | 4°C | |||||||
| Expiry | 36 months from the date of manufacture | |||||||
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