| CBP73265 | |
| I. Introduction | |
Cell Line Name： | NCOA4-RET/BaF3 |
Host Cell: | BA/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
NCOA4, nuclear receptor coactivator 4, is an androgen receptor coactivator (PMID: 15166229) and autophagy receptor that degrades ferritin complexes (PMID: 31061094) and plays a role in iron homeostasis (PMID: 30930742). NCOA4 fusions are frequently observed with RET in papillary thyroid carcinoma (also referred to as RET/PTC3) (PMID: 25731779) and have been reported in salivary intraductal carcinoma (PMID: 31162284), spindle cell tumors (PMID: 30938880), breast cancer (PMID: 30446652), colorectal cancer (PMID: 30210625), and lung cancer (PMID: 30038711). | |
| III. Representative Data | |
1. WB of NCOA4-RET/BaF3
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2. Anti-proliferation assay | |
Figure 2. CTG assay of for NCOA4-RET/BaF3 Stable Cell Line. | |
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