| CBP73372 | |
| I. Introduction | |
Cell Line Name： | KRAS G12C-R68M/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
Mycoplasma Status: | Negative |
| II.Background | |
KRAS, KRAS proto-oncogene, GTPase, is a member of the small GTPase superfamily and a key regulator of the MAPK, PI3K/AKT/mTOR pathways (PMID: 23622131). KRAS mutations are identified in a wide range of cancers (PMID: 28666118). | |
| III. Representative Data | |
1.Sanger of KRAS G12C-R68M/BaF3
Figure 1. KRAS(NM_033360.4):c.34G>T p.G12C
Figure 2. KRAS(NM_004985.5): c.203G>T p.R68M | |
2. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of KRAS G12C/R68M BaF3 Cells (C2). | |
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