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產品名稱：SMPH
英文名稱：(succinimidyl-6-((b-maleimidopropionamido)hexanoate)
簡介：SMPH crosslinker (Succinimidyl-6-[ß-maleimidopropionamido]hexanoate) is a water insoluble, heterobifunctional protein crosslinker with a non-cleavable spacer arm length of 14.3 angstroms. The SMPH crosslinking reagent has maleimide groups which are reactive to thiols (sufhydryls) and its NHS ester groups react with amines at pH 6.5-7.5 and 7-9, respectively
General description
SMPH is a heterobifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while the maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values greater than 7.5. For these reasons, conjugation experiments involving this type of heterobifunctional crosslinker are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
結構式：
外觀：白色粉末
Molecular Weight: 379.4
分子式：C17H21N3O7
溶解：DMSO or DMF
Alternative Name: Succinimidyl-6-[βmaleimidopropionamido] hexanoate
純度：98%+
保存：-20℃
：西安瑞禧生物科技有限公司
產品名稱：SPDP
英文名稱：N-Succinimidyl 3-(2-Pyridyldithio)propionate
中文名稱：3-(2-吡啶基二硫基)丙酸N-羥基琥珀酰亞胺酯
CAS #: 68181-17-9
簡介：SPDP crosslinker is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobi-functional protein crosslinker. The SPDP crosslinking reagent's reactive moites consist of an N-hydroxysuccinimide (NHS) ester that reacts with primary amines. On the other end of SPDP, the pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond.
Application
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.
外觀：白色粉末
Molecular Weight: 312.4
分子式:C12H12N2O4S2
CAS #: 68181-17-9
溶解：DMSO or DMF
Spacer Length: 6.8 Å
Alternative Name: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
純度：98%+
保存：-20℃
：西安瑞禧生物科技有限公司
以上資料源于西安瑞禧生物科技有限公司
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