上海科敏生物銷售MyoD1 Antibody #12344 Cell Signaling，CST原裝品質，*，訂購MyoD1 Antibody #12344 Cell Signaling，詳情請咨詢銷售人員！
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產品名稱：
貨號：12344
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型：Polyclonal
規格：

抗體應用：

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on * sequence homology.
特異性/敏感度：MyoD1 Antibody recognizes endogenous levels of total MyoD1 protein. This antibody also detects a 142 kDa protein of unknown origin.
來源及純化方法：Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly228 of human MyoD1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗體背景：

Myoblast determination protein 1 (MyoD1), also called myogenic factor 3 (Myf3), is a member of the MyoD family of muscle­specific bHLH transcription factors (1). This family is responsible for controlling specification of the muscle cell lineage and is expressed only in skeletal muscle and its precursors. MyoD1 is considered a master regulator of skeletal myogenesis as its expression can induce myogenic differentiation in myoblasts, fibroblasts, and a variety of other cell types (2,3). Through ChIP-sequencing experiments, researchers have discovered that MyoD is associated with the promoters of many genes in muscle cells, but it only regulates a subset of those genes. Recent studies point to regulation of MyoD transcriptional activity via epigenetic mechanisms involving SWI/SNF complexes and Polycomb and Trithorax Group proteins (4-6). Additional influences on muscle development include signal transduction through MAPK, PI3K/Akt, myostatin, NF-κB, and mTOR signaling pathways (5-7).

關鍵詞：CST，抗體，一抗{byao_back}{byao_back2}

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