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【產品簡介】
【詳細說明】
APETx2
ASIC3 selective inhibitor(酸敏感離子通道3 (ASIC3 )選擇性抑制劑) |
APETx2 is a toxin that was originally isolated from Anthopleura elegantissima (Sea anemone).APETx2 selectively blocks the H(+)-gated sodium channel ASIC3 (ACCN3). The blockage is rapid and reversible. This toxin does not block isoform ASIC1a (unlike Psalmotoxin 1) and isoform ASIC1b of ASIC1 (ACCN2), nor ASIC2 (ACCN1). It also inhibits the heteromeric ASIC2b-ASIC3 channel, and has less affinity for ASIC1b-ASIC3, ASIC1a-ASIC3, and no effect on the ASIC2a-ASIC3 channels. IC50 is 63 nM on ASIC3 channel. IC50 is 117 nM on ASIC2b-ASIC3 heteromeric channel. IC50 is 0.9 µM on ASIC1b-ASIC3 heteromeric channel. IC50 is 2 µM on ASIC1a-ASIC3 heteromeric channel. Interestingly, recent studies demonstrated that APETx2also inhibits Nav1.8 currents with an IC50 of around 2 µM.
APETx2技術資料
氨基酸序列：
H-Gly-Thr-Ala-Cys4-Ser-Cys6-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys20-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys30-Arg-Tyr-Phe-Leu-Gly-Thr-Cys37-Cys38-Thr-Pro-Ala-Asp-OH
二硫鍵： Disulfide bonds between Cys4-Cys37, Cys6-Cys30 and Cys20-Cys38
長度 (aa)：42
分子式： C196H280N54O61S6
分子量： 4561.13 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS 號： not available
來源： Synthetic
純度： > 98%
產品信息
07APE002-00100 | APETx2 | 0.1mg |
07APE002-00500 | APETx2 | 0.5mg |
07APE002-01000 | APETx2 | 1mg |